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The usability of such sites is often questioned, but I personally think they’re great, although one important factor I’d advise considering is to tap into the user’s mouse scrollwheel to enable it to scroll the website horizontally. This is a technique employed by a bunch of the sites in this showcase, and as you’ll find when browsing, it makes them much more usable.
Enterro da Gata
How to Create Your Own Horizontally Scrolling Website
Fancy building a horizontal site of your own? Check out these handy articles and tutorials. Each one offers expert advice on the coding techniques used, and the best practices when considering going the horizontal way.
Create a Horizontal Scrolling Website